Seizure Versus Syncope

NOTE: This pathway is intended for use in patients who experienced a paroxysmal episode of loss of consciousness or alteration of awareness. If clinical suspicion for seizure is high, consider utilizing first time seizure pathway. It can be difficult to differentiate seizures from syncope, but directed questions involving the semiology of the episode and associated symptoms can help differentiate the two.

Last updated 8/27/2026

Clinical features more suggestive of seizure

Common seizure semiologies

Clinical features more suggestive of syncope

Syncope triggers

Diagnostic Evaluation